NUTM1
NUTM1 (NUT family member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Oesophageal cancer, Ovarian cancer and 4 more.
Overview
Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.84, affected pathway 0.61, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Oesophageal Adenocarcinoma, Ovarian Epithelial Tumour.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NUTM1 (NUT family member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Oesophageal cancer, Ovarian cancer and 4 more.
- 1 · What it is
NUTM1 (NUT family member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Oesophageal cancer, Ovarian cancer and 4 more.
- 2 · What goes wrong in cancer
Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.
- 3 · How drugs use it
No product in this corpus aims at NUTM1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:29919 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86Y26 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184507 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.53, melanoma 0.56, skin cancer 0.59, lung cancer 0.56 (GraphQL API, CC0)); IntOGen NUTM1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Location: Cytoplasm; Nucleus (UniProt). Locus 15q14 (HGNC).
- Skin cancer: Open Targets association 0.59 with skin cancer (MONDO_0002898)
- Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)
- Ovarian cancer: IntOGen driver in 1 cohort (OVT)
- Lung cancer: Open Targets association 0.56 with lung cancer (MONDO_0008903)
- Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)
- Melanoma: Open Targets association 0.56 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NUTM1" OR ABSTRACT:"NUTM1" OR TITLE:"NUT midline carcinoma family member 1" OR ABSTRACT:"NUT midline carcinoma family member 1" OR TITLE:"NUT family member 1" OR ABSTRACT:"NUT family member 1" OR TITLE:"DKFZp434O192" OR ABSTRACT:"DKFZp434O192" OR TITLE:"FAM22H" OR ABSTRACT:"FAM22H" OR TITLE:"C15orf55" OR ABSTRACT:"C15orf55") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUTM1, not a curated reading list.
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