PTMA
PTMA (Prothymosin alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Testicular germ cell tumours.
Overview
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Mixed Germ Cell Tumour.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PTMA (Prothymosin alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Testicular germ cell tumours.
- 1 · What it is
PTMA (Prothymosin alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Testicular germ cell tumours.
- 2 · What goes wrong in cancer
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PTMA yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:9623 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P06454 (protein name, function text, keywords and locations (REST API)); IntOGen PTMA (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Location: Nucleus (UniProt). Locus 2q37.1 (HGNC).
- Testicular germ cell tumours: IntOGen driver in 1 cohort (MGCT)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PTMA" OR ABSTRACT:"PTMA" OR TITLE:"prothymosin alpha" OR ABSTRACT:"prothymosin alpha" OR TITLE:"Prothymosin alpha" OR ABSTRACT:"Prothymosin alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTMA, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetTET1
Shares Testicular germ cell tumours, IntOGen.