HSPG2
HSPG2 (Basement membrane-specific heparan sulfate proteoglycan core protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Overview
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Bladder Urothelial Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HSPG2 (Basement membrane-specific heparan sulfate proteoglycan core protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
- 1 · What it is
HSPG2 (Basement membrane-specific heparan sulfate proteoglycan core protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
- 2 · What goes wrong in cancer
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective.
- 3 · How drugs use it
No product in this corpus aims at HSPG2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:5273 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P98160 (protein name, function text, keywords and locations (REST API)); IntOGen HSPG2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularisation. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Location: Secreted, extracellular space, extracellular matrix, basement membrane; Secreted (UniProt). Locus 1p36.12 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HSPG2" OR ABSTRACT:"HSPG2" OR TITLE:"heparan sulfate proteoglycan 2" OR ABSTRACT:"heparan sulfate proteoglycan 2" OR TITLE:"Basement membrane-specific heparan sulfate proteoglycan core protein" OR ABSTRACT:"Basement membrane-specific heparan sulfate proteoglycan core protein" OR TITLE:"perlecan" OR ABSTRACT:"perlecan" OR TITLE:"PRCAN" OR ABSTRACT:"PRCAN" OR TITLE:"SJS1" OR ABSTRACT:"SJS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSPG2, not a curated reading list.