HSPG2
HSPG2 (Basement membrane-specific heparan sulfate proteoglycan core protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularisation. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Location: Secreted, extracellular space, extracellular matrix, basement membrane; Secreted (UniProt). Locus 1p36.12 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"HSPG2" OR ABSTRACT:"HSPG2" OR TITLE:"heparan sulfate proteoglycan 2" OR ABSTRACT:"heparan sulfate proteoglycan 2" OR TITLE:"Basement membrane-specific heparan sulfate proteoglycan core protein" OR ABSTRACT:"Basement membrane-specific heparan sulfate proteoglycan core protein" OR TITLE:"perlecan" OR ABSTRACT:"perlecan" OR TITLE:"PRCAN" OR ABSTRACT:"PRCAN" OR TITLE:"SJS1" OR ABSTRACT:"SJS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSPG2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/hspg2.json. Licence CC BY-NC 4.0.