TCL1A
TCL1A (T-cell leukaemia/lymphoma protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma, Skin cancer, Diffuse large B-cell lymphoma and 1 more.
Overview
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilises mitochondrial membrane potential and promotes cell survival.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.76, genetic association 0.48, somatic mutation 0.89). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TCL1A (T-cell leukaemia/lymphoma protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma, Skin cancer, Diffuse large B-cell lymphoma and 1 more.
- 1 · What it is
TCL1A (T-cell leukaemia/lymphoma protein 1A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma, Skin cancer, Diffuse large B-cell lymphoma and 1 more.
- 2 · What goes wrong in cancer
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1.
- 3 · How drugs use it
No product in this corpus aims at TCL1A yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:11648 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P56279 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000100721 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: melanoma 0.51, non-Hodgkin lymphoma 0.56, skin cancer 0.51 (GraphQL API, CC0)); IntOGen TCL1A (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilises mitochondrial membrane potential and promotes cell survival. Location: Cytoplasm; Nucleus; Microsome; Endoplasmic reticulum (UniProt). Locus 14q32.13 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
- Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)
- Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TCL1A" OR ABSTRACT:"TCL1A" OR TITLE:"TCL1 family AKT coactivator A" OR ABSTRACT:"TCL1 family AKT coactivator A" OR TITLE:"T-cell leukemia/lymphoma protein 1A" OR ABSTRACT:"T-cell leukemia/lymphoma protein 1A" OR TITLE:"TCL1" OR ABSTRACT:"TCL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TCL1A, not a curated reading list.