STAT6
STAT6 (Signal transducer and activator of transcription 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Diffuse large B-cell lymphoma.
Overview
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signalling.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.98, animal model 0.31, genetic association 0.08, somatic mutation 0.89). IntOGen calls it a driver in 4 cohorts (4 activating, 0 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · STAT6 (Signal transducer and activator of transcription 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Diffuse large B-cell lymphoma.
- 1 · What it is
STAT6 (Signal transducer and activator of transcription 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Diffuse large B-cell lymphoma.
- 2 · What goes wrong in cancer
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signalling.
- 3 · How drugs use it
No product in this corpus aims at STAT6 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:11368 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P42226 (protein name, function text, keywords and locations (REST API)); CIViC gene STAT6 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000166888 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: diffuse large B-cell lymphoma 0.51, non-Hodgkin lymphoma 0.65 (GraphQL API, CC0)); IntOGen STAT6 (driver in 4 cohorts (Act 4, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signalling. Location: Cytoplasm; Nucleus (UniProt). Locus 12q13.3 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.65 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 2 cohorts (MLYM, NHL)
- Diffuse large B-cell lymphoma: Open Targets association 0.51 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"STAT6" OR ABSTRACT:"STAT6" OR TITLE:"signal transducer and activator of transcription 6" OR ABSTRACT:"signal transducer and activator of transcription 6" OR TITLE:"Signal transducer and activator of transcription 6" OR ABSTRACT:"Signal transducer and activator of transcription 6" OR TITLE:"D12S1644" OR ABSTRACT:"D12S1644" OR TITLE:"IL-4-STAT" OR ABSTRACT:"IL-4-STAT") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STAT6, not a curated reading list.