ZXDB
ZXDB (Zinc finger X-linked protein ZXDB) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Overview
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZXDB (Zinc finger X-linked protein ZXDB) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
- 1 · What it is
ZXDB (Zinc finger X-linked protein ZXDB) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at ZXDB yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:13199 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P98169 (protein name, function text, keywords and locations (REST API)); IntOGen ZXDB (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. Location: Nucleus (UniProt). Locus Xp11.21 (HGNC).
- Breast cancer: IntOGen driver in 1 cohort (BRCA)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZXDB" OR ABSTRACT:"ZXDB" OR TITLE:"zinc finger X-linked duplicated B" OR ABSTRACT:"zinc finger X-linked duplicated B" OR TITLE:"Zinc finger X-linked protein ZXDB" OR ABSTRACT:"Zinc finger X-linked protein ZXDB" OR TITLE:"ZNF905" OR ABSTRACT:"ZNF905") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZXDB, not a curated reading list.