PHF6
PHF6 (PHD finger protein 6) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Myeloproliferative neoplasms and 5 more.
Overview
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.97, animal model 0.29, genetic association 0.00, somatic mutation 0.91). IntOGen calls it a driver in 5 cohorts (2 activating, 3 loss-of-function), covering Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia, Burkitt Lymphoma, Lung Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PHF6 (PHD finger protein 6) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Myeloproliferative neoplasms and 5 more.
- 1 · What it is
PHF6 (PHD finger protein 6) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Myeloproliferative neoplasms and 5 more.
- 2 · What goes wrong in cancer
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. Location: Nucleus; Nucleus, nucleolus; Chromosome, centromere, kinetochore (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PHF6 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:18145 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IWS0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156531 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.53, acute lymphoblastic leukaemia 0.56, non-Hodgkin lymphoma 0.61, myeloproliferative neoplasm 0.55, breast cancer 0.52, leukaemia 0.65 (GraphQL API, CC0)); IntOGen PHF6 (driver in 5 cohorts (Act 2, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. Location: Nucleus; Nucleus, nucleolus; Chromosome, centromere, kinetochore (UniProt). Locus Xq26.2 (HGNC).
- Leukaemia: Open Targets association 0.65 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908)
- Myeloproliferative neoplasms: Open Targets association 0.55 with myeloproliferative neoplasm (MONDO_0020076)
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
- Acute myeloid leukaemia: Open Targets association 0.53 with acute myeloid leukaemia (MONDO_0018874); IntOGen driver in 2 cohorts (AML)
- Acute lymphoblastic leukaemia: Open Targets association 0.56 with acute lymphoblastic leukaemia (MONDO_0004967); IntOGen driver in 1 cohort (ALL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PHF6" OR ABSTRACT:"PHF6" OR TITLE:"PHD finger protein 6" OR ABSTRACT:"PHD finger protein 6" OR TITLE:"KIAA1823" OR ABSTRACT:"KIAA1823" OR TITLE:"MGC14797" OR ABSTRACT:"MGC14797" OR TITLE:"CENP-31" OR ABSTRACT:"CENP-31") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PHF6, not a curated reading list.
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