CDH10
CDH10 (Cadherin-10) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Endometrial cancer and Non-small-cell lung cancer.
Overview
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
IntOGen calls it a driver in 6 cohorts (3 activating, 2 loss-of-function), covering Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Pancreatic Adenocarcinoma, Endometrial Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CDH10 (Cadherin-10) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Endometrial cancer and Non-small-cell lung cancer.
- 1 · What it is
CDH10 (Cadherin-10) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Endometrial cancer and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
- 3 · How drugs use it
No product in this corpus aims at CDH10 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:1749 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6N8 (protein name, function text, keywords and locations (REST API)); IntOGen CDH10 (driver in 6 cohorts (Act 3, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Location: Cell membrane (UniProt). Locus 5p14.2-p14.1 (HGNC).
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
- Endometrial cancer: IntOGen driver in 1 cohort (UCEC)
- Non-small-cell lung cancer: IntOGen driver in 4 cohorts (LUAD, LUSC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CDH10" OR ABSTRACT:"CDH10" OR TITLE:"cadherin 10" OR ABSTRACT:"cadherin 10" OR TITLE:"Cadherin-10" OR ABSTRACT:"Cadherin-10") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDH10, not a curated reading list.