FUBP1
FUBP1 (Far upstream element-binding protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 2 more.
Overview
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.54, somatic mutation 0.77). IntOGen calls it a driver in 4 cohorts (2 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Low-Grade Glioma, NOS.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FUBP1 (Far upstream element-binding protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 2 more.
- 1 · What it is
FUBP1 (Far upstream element-binding protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 2 more.
- 2 · What goes wrong in cancer
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
- 3 · How drugs use it
No product in this corpus aims at FUBP1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:4004 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96AE4 (protein name, function text, keywords and locations (REST API)); CIViC gene FUBP1 (1 evidence items, 0 assertions, 1 variants; diseases: Oligodendroglioma (GraphQL API, CC0)); Open Targets ENSG00000162613 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.54, skin cancer 0.61, lung cancer 0.50 (GraphQL API, CC0)); IntOGen FUBP1 (driver in 4 cohorts (Act 2, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. Location: Nucleus (UniProt). Locus 1p31.1 (HGNC).
- Skin cancer: Open Targets association 0.61 with skin cancer (MONDO_0002898)
- Breast cancer: IntOGen driver in 1 cohort (BRCA)
- Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)
- Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)
- Chronic lymphocytic leukaemia: IntOGen driver in 1 cohort (CLLSLL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Oligodendroglioma; Low-Grade Glioma, NOS.
Latest papers
topQuery for this target: (TITLE:"FUBP1" OR ABSTRACT:"FUBP1" OR TITLE:"far upstream element binding protein 1" OR ABSTRACT:"far upstream element binding protein 1" OR TITLE:"Far upstream element-binding protein 1" OR ABSTRACT:"Far upstream element-binding protein 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FUBP1, not a curated reading list.
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