PCM1
PCM1 (Pericentriolar material 1 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Overview
Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.46, somatic mutation 0.74). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Glioblastoma Multiforme.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PCM1 (Pericentriolar material 1 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
- 1 · What it is
PCM1 (Pericentriolar material 1 protein) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
- 2 · What goes wrong in cancer
Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2.
- 3 · How drugs use it
No product in this corpus aims at PCM1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:8727 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15154 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000078674 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0)); IntOGen PCM1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Required for centrosome assembly and function. Essential for the correct localisation of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites. Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasmic granule; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite (UniProt). Locus 8p22 (HGNC).
- Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PCM1" OR ABSTRACT:"PCM1" OR TITLE:"pericentriolar material 1" OR ABSTRACT:"pericentriolar material 1" OR TITLE:"Pericentriolar material 1 protein" OR ABSTRACT:"Pericentriolar material 1 protein" OR TITLE:"PTC4" OR ABSTRACT:"PTC4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PCM1, not a curated reading list.