RAP1B
RAP1B (Ras-related protein Rap-1b) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
Overview
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarising activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localisation of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.97, genetic association 0.00, somatic mutation 0.44). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RAP1B (Ras-related protein Rap-1b) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
- 1 · What it is
RAP1B (Ras-related protein Rap-1b) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer.
- 2 · What goes wrong in cancer
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarising activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen.
- 3 · How drugs use it
No product in this corpus aims at RAP1B yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:9857 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P61224 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000127314 (association with cancer (MONDO_0004992) 0.69; (GraphQL API, CC0)); IntOGen RAP1B (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarising activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localisation of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. Location: Cell membrane; Cytoplasm, cytosol; Cell junction (UniProt). Locus 12q15 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RAP1B" OR ABSTRACT:"RAP1B" OR TITLE:"RAP1B, member of RAS oncogene family" OR ABSTRACT:"RAP1B, member of RAS oncogene family" OR TITLE:"Ras-related protein Rap-1b" OR ABSTRACT:"Ras-related protein Rap-1b" OR TITLE:"K-REV" OR ABSTRACT:"K-REV" OR TITLE:"RAL1B" OR ABSTRACT:"RAL1B" OR TITLE:"DKFZp586H0723" OR ABSTRACT:"DKFZp586H0723") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAP1B, not a curated reading list.