RBM10
RBM10 (Ribosome biogenesis inhibitor MINAS-60) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer and 4 more.
Overview
Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus.
Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes literature 0.98, animal model 0.43, genetic association 0.00, somatic mutation 0.97). IntOGen calls it a driver in 16 cohorts (1 activating, 15 loss-of-function), covering Bladder Urothelial Carcinoma, Cholangiocarcinoma, Colorectal Adenocarcinoma, Lung Adenocarcinoma, Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RBM10 (Ribosome biogenesis inhibitor MINAS-60) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer and 4 more.
- 1 · What it is
RBM10 (Ribosome biogenesis inhibitor MINAS-60) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer and 4 more.
- 2 · What goes wrong in cancer
Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus. Location: Nucleus, nucleolus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at RBM10 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:9896 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P0DW28 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000182872 (association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.69, colorectal cancer 0.60, urinary bladder cancer 0.59, lung cancer 0.69, biliary tract cancer 0.58 (GraphQL API, CC0)); IntOGen RBM10 (driver in 16 cohorts (Act 1, LoF 15); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Acts as a late-stage inhibitor of pre-60S ribosome assembly by preventing pre-60S ribosome export from nucleus. Location: Nucleus, nucleolus (UniProt). Locus Xp11.3 (HGNC).
- Lung cancer: Open Targets association 0.69 with lung cancer (MONDO_0008903)
- Pancreatic ductal adenocarcinoma: IntOGen driver in 4 cohorts (PAAD)
- Colorectal cancer: Open Targets association 0.60 with colorectal cancer (MONDO_0005575); IntOGen driver in 2 cohorts (COADREAD)
- Bladder & urothelial cancer: Open Targets association 0.59 with urinary bladder cancer (MONDO_0001187); IntOGen driver in 2 cohorts (BLCA)
- Biliary tract cancer: Open Targets association 0.58 with biliary tract cancer (MONDO_0003060)
- Non-small-cell lung cancer: Open Targets association 0.69 with non-small cell lung carcinoma (MONDO_0005233); IntOGen driver in 7 cohorts (LUAD, NSCLC)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 15 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RBM10" OR ABSTRACT:"RBM10" OR TITLE:"RNA binding motif protein 10" OR ABSTRACT:"RNA binding motif protein 10" OR TITLE:"Ribosome biogenesis inhibitor MINAS-60" OR ABSTRACT:"Ribosome biogenesis inhibitor MINAS-60" OR TITLE:"DXS8237E" OR ABSTRACT:"DXS8237E" OR TITLE:"KIAA0122" OR ABSTRACT:"KIAA0122" OR TITLE:"GPATC9" OR ABSTRACT:"GPATC9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBM10, not a curated reading list.
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