TERT
TERT (Telomerase reverse transcriptase) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Leukaemia, Lung cancer and 5 more.
Overview
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells.
CIViC holds 18 clinical evidence items and 0 assertions across 8 variants, naming UO126, Larotrectinib and Iodine I-131. Open Targets scores its association with cancer at 0.86 (direct and indirect evidence; datatypes genetic literature 0.91, clinical 0.50, affected pathway 0.61, literature 1.00, genetic association 0.86, somatic mutation 0.90, animal model 0.27). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Papillary Renal Cell Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TERT (Telomerase reverse transcriptase) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Leukaemia, Lung cancer and 5 more.
- 1 · What it is
TERT (Telomerase reverse transcriptase) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Leukaemia, Lung cancer and 5 more.
- 2 · What goes wrong in cancer
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells.
- 3 · How drugs use it
No product in this corpus aims at TERT yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:11730 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14746 (protein name, function text, keywords and locations (REST API)); CIViC gene TERT (18 evidence items, 0 assertions, 8 variants; diseases: Glioblastoma, Thyroid Cancer, Brain Glioma, Papillary Thyroid Carcinoma, Clear Cell Renal Cell Carcinoma and 5 more (GraphQL API, CC0)); Open Targets ENSG00000164362 (association with cancer (MONDO_0004992) 0.86; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.60, colorectal cancer 0.61, gastric cancer 0.51, hepatocellular carcinoma 0.60, prostate cancer 0.61, urinary bladder cancer 0.64 (GraphQL API, CC0)); IntOGen TERT (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyses the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. Location: Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus; Chromosome, telomere (UniProt). Locus 5p15.33 (HGNC).
- Myeloproliferative neoplasms: Open Targets association 0.75 with myeloproliferative neoplasm (MONDO_0020076)
- Leukaemia: Open Targets association 0.75 with leukaemia (MONDO_0005059)
- Lung cancer: Open Targets association 0.68 with lung cancer (MONDO_0008903)
- Skin cancer: Open Targets association 0.66 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.66 with breast cancer (MONDO_0007254)
- Bladder & urothelial cancer: Open Targets association 0.64 with urinary bladder cancer (MONDO_0001187); CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.82; IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 18 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Brain Glioma; Papillary Thyroid Carcinoma; Acral Lentiginous Melanoma.
Latest papers
topQuery for this target: (TITLE:"TERT" OR ABSTRACT:"TERT" OR TITLE:"telomerase reverse transcriptase" OR ABSTRACT:"telomerase reverse transcriptase" OR TITLE:"Telomerase reverse transcriptase" OR ABSTRACT:"Telomerase reverse transcriptase" OR TITLE:"TP2" OR ABSTRACT:"TP2" OR TITLE:"TCS1" OR ABSTRACT:"TCS1" OR TITLE:"hEST2" OR ABSTRACT:"hEST2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TERT, not a curated reading list.
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