SETBP1
SETBP1 (SET-binding protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Breast cancer and 5 more.
Overview
UniProt has no function text for Q9Y6X0; HGNC names it "SET binding protein 1".
CIViC holds 3 clinical evidence items and 0 assertions across 3 variants. Open Targets scores its association with cancer at 0.84 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.83, somatic mutation 0.84, genetic literature 0.83). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Adrenocortical Carcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SETBP1 (SET-binding protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Breast cancer and 5 more.
- 1 · What it is
SETBP1 (SET-binding protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Breast cancer and 5 more.
- 2 · What goes wrong in cancer
UniProt has no function text for Q9Y6X0; HGNC names it "SET binding protein 1". Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at SETBP1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:15573 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6X0 (protein name, function text, keywords and locations (REST API)); CIViC gene SETBP1 (3 evidence items, 0 assertions, 3 variants; diseases: Chronic Myeloid Leukaemia, Juvenile Myelomonocytic Leukaemia, Atypical Chronic Myeloid Leukaemia, BCR-ABL1 Negative (GraphQL API, CC0)); Open Targets ENSG00000152217 (association with cancer (MONDO_0004992) 0.84; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.51, gastric cancer 0.51, melanoma 0.57, neuroendocrine neoplasm 0.52, acute myeloid leukaemia 0.67, skin cancer 0.57 (GraphQL API, CC0)); IntOGen SETBP1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for Q9Y6X0; HGNC names it "SET binding protein 1". Location: Nucleus (UniProt). Locus 18q12.3 (HGNC).
- Myeloproliferative neoplasms: Open Targets association 0.77 with myeloproliferative neoplasm (MONDO_0020076)
- Leukaemia: Open Targets association 0.77 with leukaemia (MONDO_0005059)
- Breast cancer: Open Targets association 0.66 with breast cancer (MONDO_0007254)
- Myelodysplastic syndromes / neoplasms: Open Targets association 0.66 with myelodysplastic syndrome (MONDO_0018881)
- Adrenocortical carcinoma: IntOGen driver in 1 cohort (ACC)
- Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 3 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Juvenile Myelomonocytic Leukaemia; Atypical Chronic Myeloid Leukaemia, BCR-ABL1 Negative.
Latest papers
topQuery for this target: (TITLE:"SETBP1" OR ABSTRACT:"SETBP1" OR TITLE:"SET binding protein 1" OR ABSTRACT:"SET binding protein 1" OR TITLE:"SET-binding protein" OR ABSTRACT:"SET-binding protein" OR TITLE:"KIAA0437" OR ABSTRACT:"KIAA0437") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SETBP1, not a curated reading list.
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