FCRL4
FCRL4 (Fc receptor-like protein 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Skin cancer, Lung cancer and 2 more.
Overview
May function as an inhibitor of the B-cell receptor signalling. May function in the B-cell-mediated immune response.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.39, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FCRL4 (Fc receptor-like protein 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Skin cancer, Lung cancer and 2 more.
- 1 · What it is
FCRL4 (Fc receptor-like protein 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Skin cancer, Lung cancer and 2 more.
- 2 · What goes wrong in cancer
May function as an inhibitor of the B-cell receptor signalling. May function in the B-cell-mediated immune response.
- 3 · How drugs use it
No product in this corpus aims at FCRL4 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
External identifiers
Sources: HGNC HGNC:18507 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96PJ5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163518 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.56, breast cancer 0.51, lung cancer 0.54 (GraphQL API, CC0)); IntOGen FCRL4 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
May function as an inhibitor of the B-cell receptor signalling. May function in the B-cell-mediated immune response. Location: Cell membrane (UniProt). Locus 1q23.1 (HGNC).
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
- Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FCRL4" OR ABSTRACT:"FCRL4" OR TITLE:"Fc receptor like 4" OR ABSTRACT:"Fc receptor like 4" OR TITLE:"Fc receptor-like protein 4" OR ABSTRACT:"Fc receptor-like protein 4" OR TITLE:"FCRH4" OR ABSTRACT:"FCRH4" OR TITLE:"IRTA1" OR ABSTRACT:"IRTA1" OR TITLE:"IGFP2" OR ABSTRACT:"IGFP2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FCRL4, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetACVR1B
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetAFDN
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetATP2B3
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetIKBKB
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetMAP3K13
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), Melanoma.
- TargetMRTFA
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), Melanoma.
- TargetSMAD3
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.
- TargetCBLB
Shares Lung cancer (all types), Skin cancer (all types), Breast cancer (all types), IntOGen.