PARP4
PARP4 (Protein mono-ADP-ribosyltransferase PARP4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Multiple myeloma and Non-small-cell lung cancer.
Overview
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction.
IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Colorectal Adenocarcinoma, Lung Adenocarcinoma, Plasma Cell Myeloma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PARP4 (Protein mono-ADP-ribosyltransferase PARP4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Multiple myeloma and Non-small-cell lung cancer.
- 1 · What it is
PARP4 (Protein mono-ADP-ribosyltransferase PARP4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Multiple myeloma and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction.
- 3 · How drugs use it
No product in this corpus aims at PARP4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:271 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UKK3 (protein name, function text, keywords and locations (REST API)); IntOGen PARP4 (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction. Location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 13q12.12 (HGNC).
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
- Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PARP4" OR ABSTRACT:"PARP4" OR TITLE:"poly ADP-ribose polymerase family member 4" OR ABSTRACT:"poly ADP-ribose polymerase family member 4" OR TITLE:"Protein mono-ADP-ribosyltransferase PARP4" OR ABSTRACT:"Protein mono-ADP-ribosyltransferase PARP4" OR TITLE:"VAULT3" OR ABSTRACT:"VAULT3" OR TITLE:"p193" OR ABSTRACT:"p193" OR TITLE:"VPARP" OR ABSTRACT:"VPARP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PARP4, not a curated reading list.