BCL7A
BCL7A (B-cell CLL/lymphoma 7 protein family member A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and 1 more.
Overview
UniProt has no function text for Q4VC05; HGNC names it "BAF chromatin remodeling complex subunit BCL7A".
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant. IntOGen calls it a driver in 4 cohorts (4 activating, 0 loss-of-function), covering Burkitt Lymphoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Plasma Cell Myeloma.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BCL7A (B-cell CLL/lymphoma 7 protein family member A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and 1 more.
- 1 · What it is
BCL7A (B-cell CLL/lymphoma 7 protein family member A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Diffuse large B-cell lymphoma and 1 more.
- 2 · What goes wrong in cancer
UniProt has no function text for Q4VC05; HGNC names it "BAF chromatin remodeling complex subunit BCL7A". Locus 12q24.31 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at BCL7A yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
External identifiers
Sources: HGNC HGNC:1004 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q4VC05 (protein name, function text, keywords and locations (REST API)); CIViC gene BCL7A (2 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)); IntOGen BCL7A (driver in 4 cohorts (Act 4, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Biology
UniProt has no function text for Q4VC05; HGNC names it "BAF chromatin remodeling complex subunit BCL7A". Locus 12q24.31 (HGNC).
- Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (MLYM)
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
- Diffuse large B-cell lymphoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (DLBCLNOS)
- Burkitt lymphoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (BL)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; CIViC holds 2 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BCL7A" OR ABSTRACT:"BCL7A" OR TITLE:"BAF chromatin remodeling complex subunit BCL7A" OR ABSTRACT:"BAF chromatin remodeling complex subunit BCL7A" OR TITLE:"B-cell CLL/lymphoma 7 protein family member A" OR ABSTRACT:"B-cell CLL/lymphoma 7 protein family member A" OR TITLE:"SMARCJ1" OR ABSTRACT:"SMARCJ1" OR TITLE:"BCL7" OR ABSTRACT:"BCL7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BCL7A, not a curated reading list.
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