AXIN1
AXIN1 (Axin-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Oesophageal cancer, Skin cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signalling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signalling pathway and ventralise embryos, but also dorsalises embryos by activating a Wnt-independent JNK signalling pathway. In Wnt signalling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Enhances TGF-beta signalling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Location: Cytoplasm; Nucleus; Membrane; Cell membrane (UniProt). Locus 16p13.3 (HGNC).
- Hepatocellular carcinoma: Open Targets association 0.79 with hepatocellular carcinoma (MONDO_0007256); IntOGen driver in 7 cohorts (HCC)
- Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)
- Leukaemia: Open Targets association 0.50 with leukaemia (MONDO_0005059)
- Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"AXIN1" OR ABSTRACT:"AXIN1" OR TITLE:"axin 1" OR ABSTRACT:"axin 1" OR TITLE:"Axin-1" OR ABSTRACT:"Axin-1" OR TITLE:"PPP1R49" OR ABSTRACT:"PPP1R49") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AXIN1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/axin1.json. Licence CC BY-NC 4.0.