BCL11B
BCL11B (B-cell lymphoma/leukaemia 11B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer, Non-Hodgkin lymphoma, Skin cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of haematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumour-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element. May also function in the P53-signalling pathway. Location: Nucleus (UniProt). Locus 14q32.2 (HGNC).
- Vulvar cancer: IntOGen driver in 1 cohort (VULVA)
- Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)
- Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)
- Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059)
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"BCL11B" OR ABSTRACT:"BCL11B" OR TITLE:"BCL11 transcription factor B" OR ABSTRACT:"BCL11 transcription factor B" OR TITLE:"B-cell lymphoma/leukemia 11B" OR ABSTRACT:"B-cell lymphoma/leukemia 11B" OR TITLE:"CTIP-2" OR ABSTRACT:"CTIP-2" OR TITLE:"CTIP2" OR ABSTRACT:"CTIP2" OR TITLE:"hRIT1-alpha" OR ABSTRACT:"hRIT1-alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BCL11B, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/bcl11b.json. Licence CC BY-NC 4.0.