BIRC6
BIRC6 (Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Breast cancer, Renal cell carcinoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase. Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide. Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6. Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent. Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2. Location: Golgi apparatus, trans-Golgi network membrane; Endosome; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 2p22.3 (HGNC).
- Bladder & urothelial cancer: IntOGen driver in 3 cohorts (BLCA)
- Breast cancer: IntOGen driver in 2 cohorts (BRCA)
- Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC)
- Endometrial cancer: IntOGen driver in 2 cohorts (UCEC)
- Anal cancer: IntOGen driver in 1 cohort (ANSC)
- Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"BIRC6" OR ABSTRACT:"BIRC6" OR TITLE:"baculoviral IAP repeat containing 6" OR ABSTRACT:"baculoviral IAP repeat containing 6" OR TITLE:"Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6" OR ABSTRACT:"Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6" OR TITLE:"BRUCE" OR ABSTRACT:"BRUCE") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BIRC6, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/birc6.json. Licence CC BY-NC 4.0.