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CDC7 is the kinase that switches on the starting points of DNA copying in each cell cycle. Cancer cells starved of it attempt to copy their DNA anyway and die, while normal cells pause; a CDC7 inhibitor is in trials for acute myeloid leukaemia and myelodysplastic syndromes. This dossier gathers the 1 product (0 approved), 1 trial, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Kinase that phosphorylates MCM proteins and claspin, substrates that regulate the G1/S transition and the start of DNA replication (UniProt O00311).
| Modality | Phase 1 |
|---|---|
| Small molecule 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 1 | Historic | A First-In-Human, Phase 1, Dose Escalation Study of SGR-2921 as Monotherapy In Subjects With Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CDC7" OR ABSTRACT:"CDC7" OR TITLE:"cell division cycle 7" OR ABSTRACT:"cell division cycle 7" OR TITLE:"CDC7 kinase" OR ABSTRACT:"CDC7 kinase" OR TITLE:"DDK" OR ABSTRACT:"DDK") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDC7, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/cdc7.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cdc7.json. Licence CC BY-NC 4.0.