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CDK11 is an enzyme that helps the cell's splicing machinery cut and join its gene messages correctly. Blocking it leaves messages unfinished; one CDK11 inhibitor is in preclinical development. This dossier gathers the 1 product (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Cyclin-dependent kinase with several isoforms, one of them expressed specifically in the G2 and M phases of the cell cycle (UniProt P21127). Because the two genes are near-identical, the record carries both in its cross-references and no single gene id.
| Modality | Preclinical |
|---|---|
| Small molecule 1 |
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CDK11" OR ABSTRACT:"CDK11" OR TITLE:"cyclin dependent kinase 11" OR ABSTRACT:"cyclin dependent kinase 11" OR TITLE:"CDK11A" OR ABSTRACT:"CDK11A" OR TITLE:"CDK11B" OR ABSTRACT:"CDK11B" OR TITLE:"PITSLRE" OR ABSTRACT:"PITSLRE") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDK11, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/cdk11.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cdk11.json. Licence CC BY-NC 4.0.