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CDK11 is an enzyme that helps the cell's splicing machinery cut and join its gene messages correctly. Blocking it leaves messages unfinished; one CDK11 inhibitor is in preclinical development.
CDK11 is encoded by two near-identical genes on chromosome 1p36.33, CDK11A and CDK11B (HGNC). CDK11B is a cyclin-dependent kinase that regulates transcription and pre-mRNA splicing: it phosphorylates the splicing factor SF3B1 so the spliceosome can become active, and phosphorylates RNA polymerase II (UniProt P21127). A 2022 Nature study showed that inhibiting CDK11 with the selective inhibitor OTS964 stops the spliceosome moving from its precatalytic to its activated form and leads to widespread intron retention (Hluchý et al., doi:10.1038/s41586-022-05204-z). In OnCo, ACR-6840 is a preclinical CDK11 inhibitor from Acrivon's cell-cycle programme.
In plain words · CDK11 is an enzyme that helps the cell's splicing machinery cut and join its gene messages correctly. Blocking it leaves messages unfinished; one CDK11 inhibitor is in preclinical development.
CDK11 is an enzyme that helps the cell's splicing machinery cut and join its gene messages correctly. Blocking it leaves messages unfinished; one CDK11 inhibitor is in preclinical development.
Cyclin-dependent kinase with several isoforms, one of them expressed specifically in the G2 and M phases of the cell cycle (UniProt P21127).
1 product aims at CDK11: small molecules. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Cyclin-dependent kinase with several isoforms, one of them expressed specifically in the G2 and M phases of the cell cycle (UniProt P21127). Because the two genes are near-identical, the record carries both in its cross-references and no single gene id.
ACR-6840 is an experimental small molecule from Acrivon Therapeutics, in preclinical development for cancer.
Query for this target: (TITLE:"CDK11" OR ABSTRACT:"CDK11" OR TITLE:"cyclin dependent kinase 11" OR ABSTRACT:"cyclin dependent kinase 11" OR TITLE:"CDK11A" OR ABSTRACT:"CDK11A" OR TITLE:"CDK11B" OR ABSTRACT:"CDK11B" OR TITLE:"PITSLRE" OR ABSTRACT:"PITSLRE") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDK11, not a curated reading list.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline-gap-target.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline-gap-target.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline-gap-target.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline-gap-target.
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