CDK12
CDK12 (Cyclin-dependent kinase 12) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer, Breast cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to oestrogen inhibitors. Location: Nucleus; Nucleus speckle (UniProt). Locus 17q12 (HGNC).
- Prostate cancer: Open Targets association 0.67 with prostate cancer (MONDO_0008315); CIViC evidence names this disease
- Ovarian cancer: Open Targets association 0.58 with ovarian cancer (MONDO_0008170); CIViC evidence names this disease
- Breast cancer: CIViC evidence names this disease
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
- Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)
- Cervical cancer: IntOGen driver in 1 cohort (CESC)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"CDK12" OR ABSTRACT:"CDK12" OR TITLE:"cyclin dependent kinase 12" OR ABSTRACT:"cyclin dependent kinase 12" OR TITLE:"Cyclin-dependent kinase 12" OR ABSTRACT:"Cyclin-dependent kinase 12" OR TITLE:"CRK7" OR ABSTRACT:"CRK7" OR TITLE:"KIAA0904" OR ABSTRACT:"KIAA0904" OR TITLE:"CRKRS" OR ABSTRACT:"CRKRS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDK12, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/cdk12.json. Licence CC BY-NC 4.0.