DDX6 (Probable ATP-dependent RNA helicase DDX6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Lung cancer, Leiomyosarcoma and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Location: Cytoplasm, P-body; Cytoplasm; Nucleus; Cytoplasm, Cytoplasmic ribonucleoprotein granule (UniProt). Locus 11q23.3 (HGNC).
- Sarcomas: IntOGen driver in 1 cohort (LMS)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Leiomyosarcoma: IntOGen driver in 1 cohort (LMS)
- Medulloblastoma: IntOGen driver in 1 cohort (MBL)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"DDX6" OR ABSTRACT:"DDX6" OR TITLE:"DEAD-box helicase 6" OR ABSTRACT:"DEAD-box helicase 6" OR TITLE:"Probable ATP-dependent RNA helicase DDX6" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX6" OR TITLE:"Rck/p54" OR ABSTRACT:"Rck/p54" OR TITLE:"HLR2" OR ABSTRACT:"HLR2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX6, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ddx6.json. Licence CC BY-NC 4.0.