FAT4 (Protocadherin Fat 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Colorectal cancer, Hepatocellular carcinoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. Location: Membrane (UniProt). Locus 4q28.1 (HGNC).
- Prostate cancer: IntOGen driver in 4 cohorts (PRAD)
- Colorectal cancer: Open Targets association 0.62 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COADREAD)
- Hepatocellular carcinoma: IntOGen driver in 3 cohorts (HCC)
- Breast cancer: Open Targets association 0.60 with breast cancer (MONDO_0007254); IntOGen driver in 2 cohorts (BRCA)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.56 with gastric cancer (MONDO_0001056); IntOGen driver in 2 cohorts (STAD, STOMACH)
- Oesophageal cancer: Open Targets association 0.50 with oesophageal cancer (MONDO_0007576); IntOGen driver in 2 cohorts (ESCA)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"FAT4" OR ABSTRACT:"FAT4" OR TITLE:"FAT atypical cadherin 4" OR ABSTRACT:"FAT atypical cadherin 4" OR TITLE:"Protocadherin Fat 4" OR ABSTRACT:"Protocadherin Fat 4" OR TITLE:"CDHF14" OR ABSTRACT:"CDHF14" OR TITLE:"FAT-J" OR ABSTRACT:"FAT-J" OR TITLE:"CDHR11" OR ABSTRACT:"CDHR11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAT4, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/fat4.json. Licence CC BY-NC 4.0.