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MAO-A is an enzyme best known for breaking down serotonin and other signalling chemicals in the brain; medicines called MAO inhibitors, used for some neurological disorders, block it. Aggressive prostate cancers carry more of it, and a MAO-A inhibitor designed to stay out of the brain is in an early prostate cancer trial. This dossier gathers the 1 product (0 approved), 1 trial, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Amine oxidase that breaks down neuroactive and vasoactive amines and prefers serotonin as substrate (UniProt P21397).
| Modality | Phase 1 |
|---|---|
| Small molecule 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 1 | Planned | Phase I/Ib Trial of Single Agent ITR-251 in Patients With Advanced Solid Tumors With an Expansion-Phase in Metastatic Castration-Resistant Prostate Cancer | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"MAO-A" OR ABSTRACT:"MAO-A" OR TITLE:"MAOA" OR ABSTRACT:"MAOA" OR TITLE:"monoamine oxidase A" OR ABSTRACT:"monoamine oxidase A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAO-A (MAOA), not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/maoa.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/maoa.json. Licence CC BY-NC 4.0.