MAP3K1
MAP3K1 is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. Locus 5q11.2 (HGNC).
- Breast cancer: Open Targets association 0.77 with breast cancer (MONDO_0007254); IntOGen driver in 8 cohorts (BRCA)
- Ovarian cancer: Open Targets association 0.64 with ovarian cancer (MONDO_0008170)
- Endometrial cancer: Open Targets association 0.56 with endometrial cancer (MONDO_0011962); IntOGen driver in 2 cohorts (UCEC)
- Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC)
- Colorectal cancer: IntOGen driver in 2 cohorts (COAD, COADREAD)
- Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"MAP3K1" OR ABSTRACT:"MAP3K1" OR TITLE:"mitogen-activated protein kinase kinase kinase 1" OR ABSTRACT:"mitogen-activated protein kinase kinase kinase 1" OR TITLE:"Mitogen-activated protein kinase kinase kinase 1" OR ABSTRACT:"Mitogen-activated protein kinase kinase kinase 1" OR TITLE:"MAPKKK1" OR ABSTRACT:"MAPKKK1" OR TITLE:"MEKK1" OR ABSTRACT:"MEKK1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAP3K1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/map3k1.json. Licence CC BY-NC 4.0.