MAX (MYC associated transcriptional regulator X) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Multiple myeloma, Endometrial cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognises the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. Location: Nucleus; Cell projection, dendrite (UniProt). Locus 14q23.3 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.76 with neuroendocrine neoplasm (MONDO_0019496)
- Multiple myeloma: Open Targets association 0.51 with plasma cell myeloma (MONDO_0009693); IntOGen driver in 2 cohorts (PCM)
- Endometrial cancer: IntOGen driver in 2 cohorts (UCEC)
- Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)
- Small intestine cancer: IntOGen driver in 1 cohort (SIC)
- Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"MAX" OR ABSTRACT:"MAX" OR TITLE:"MYC associated transcriptional regulator X" OR ABSTRACT:"MYC associated transcriptional regulator X" OR TITLE:"bHLHd4" OR ABSTRACT:"bHLHd4" OR TITLE:"bHLHd5" OR ABSTRACT:"bHLHd5" OR TITLE:"bHLHd6" OR ABSTRACT:"bHLHd6" OR TITLE:"bHLHd7" OR ABSTRACT:"bHLHd7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAX, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/max.json. Licence CC BY-NC 4.0.