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PARG clears away the poly(ADP-ribose) chains that PARP enzymes lay down at damaged DNA. Blocking it is meant to deepen the replication stress some cancers already live with, as a partner or alternative to PARP inhibitors; two PARG inhibitors are in trials. This dossier gathers the 2 products (0 approved), 2 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Mainly an exo-glycohydrolase that releases ADP-ribose from poly(ADP-ribose) chains; it cannot remove the last ADP-ribose attached to a protein (UniProt Q86W56). It reverses what PARP1 and PARP2 build at DNA lesions.
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 2 | Planned | A Phase II Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of DAT-2645 in Patients With BRCA1/2 Deleterious Mutations or HRD-Positive Advanced/Metastatic Ovarian Cancer | - | ||
| 1 | Planned | A Phase I, Open-label, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of DAT-2645 in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DNA Damage Repair Pathway | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PARG" OR ABSTRACT:"PARG" OR TITLE:"poly ADP-ribose glycohydrolase" OR ABSTRACT:"poly ADP-ribose glycohydrolase") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PARG, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/parg.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/parg.json. Licence CC BY-NC 4.0.