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ETX-19477 is an experimental small molecule from 858 Therapeutics, in phase 1 trials for advanced solid tumours, BRCA-mutated platinum-resistant ovarian cancer and BRCA-mutated HR-positive, HER2-negative unresectable or metastatic breast cancer.
ETX-19477 is a small molecule (oral) from 858 Therapeutics. An oral, selective inhibitor of PARG (poly(ADP-ribose) glycohydrolase) that exploits cancer cell vulnerabilities related to replication stress and defects in replication fork protection. Its furthest stage is phase 1, for advanced solid tumours, BRCA-mutated platinum-resistant ovarian cancer and BRCA-mutated HR-positive, HER2-negative unresectable or metastatic breast cancer. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 NCT06395519 recruiting per v2 API; FDA Fast Track designations January and August 2026 (company news page). Whether it works in people has not been established unless a trial below reports it.
An oral, selective inhibitor of PARG (poly(ADP-ribose) glycohydrolase) that exploits cancer cell vulnerabilities related to replication stress and defects in replication fork protection. Connects to PARG.
1.ETX-19477 slips into a pocket on PARG.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"ETX-19477" OR ABSTRACT:"ETX-19477") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETX-19477, not a curated reading list.
Shares PARG, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
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