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PHLDA1 is a growth-factor-responsive gene involved in cell death; it is high in benign moles and falls as melanoma progresses. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Involved in regulation of apoptosis, possibly detachment-mediated cell death, and in the anti-apoptotic effects of IGF1; widely expressed, strongly in benign melanocytic naevi and progressively reduced in primary and metastatic melanoma at the protein level (UniProt Q8WV24).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
The resistance atlas has no route that names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PHLDA1" OR ABSTRACT:"PHLDA1" OR TITLE:"pleckstrin homology like domain family A member 1" OR ABSTRACT:"pleckstrin homology like domain family A member 1" OR TITLE:"TDAG51" OR ABSTRACT:"TDAG51") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PHLDA1, not a curated reading list.
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/phlda1.json. Licence CC BY-NC 4.0.