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PHLDA1 is a growth-factor-responsive gene involved in cell death; it is high in benign moles and falls as melanoma progresses.
UniProt describes PHLDA1 (TDAG51) as an apoptosis regulator whose protein is strong in benign naevi and progressively lost in melanoma. The PHLDA family genes are induced downstream of receptor tyrosine kinase and MAPK signalling, which puts them among the MAPK-responsive output genes read from expression.
In plain words · PHLDA1 is a growth-factor-responsive gene involved in cell death; it is high in benign moles and falls as melanoma progresses.
PHLDA1 is a growth-factor-responsive gene involved in cell death; it is high in benign moles and falls as melanoma progresses.
Involved in regulation of apoptosis, possibly detachment-mediated cell death, and in the anti-apoptotic effects of IGF1; widely expressed, strongly in benign melanocytic naevi and progressively reduced in primary and metastatic melanoma at the protein level (UniProt Q8WV24).
No product in this corpus aims at PHLDA1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Sources: HGNC HGNC:8933 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q8WV24 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Involved in regulation of apoptosis, possibly detachment-mediated cell death, and in the anti-apoptotic effects of IGF1; widely expressed, strongly in benign melanocytic naevi and progressively reduced in primary and metastatic melanoma at the protein level (UniProt Q8WV24).
Query for this target: (TITLE:"PHLDA1" OR ABSTRACT:"PHLDA1" OR TITLE:"pleckstrin homology like domain family A member 1" OR ABSTRACT:"pleckstrin homology like domain family A member 1" OR TITLE:"TDAG51" OR ABSTRACT:"TDAG51") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PHLDA1, not a curated reading list.
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Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), RAS / RAF / MEK / ERK (MAPK) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.