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PHLPP2 is a phosphatase that switches AKT off; it is lost in most colorectal cancers, which leaves the survival pathway on.
UniProt describes PHLPP2 as the phosphatase that removes the activating Ser-473 phosphate from AKT1 and equivalent sites on PKC, and records that its protein is lost in about four in five colorectal cancers. It is a case where the protein, not the transcript, tells the story: a PI3K/AKT activation state that RNA alone cannot see.
In plain words · PHLPP2 is a phosphatase that switches AKT off; it is lost in most colorectal cancers, which leaves the survival pathway on.
PHLPP2 is a phosphatase that switches AKT off; it is lost in most colorectal cancers, which leaves the survival pathway on.
Protein phosphatase that dephosphorylates Ser-473 of AKT1 and hydrophobic-motif sites of PKC isoforms; expression lost or significantly decreased in about 80 percent of tested colorectal tumours at the protein level (UniProt Q6ZVD8).
No product in this corpus aims at PHLPP2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Sources: HGNC HGNC:29149 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q6ZVD8 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Protein phosphatase that dephosphorylates Ser-473 of AKT1 and hydrophobic-motif sites of PKC isoforms; expression lost or significantly decreased in about 80 percent of tested colorectal tumours at the protein level (UniProt Q6ZVD8).
Query for this target: (TITLE:"PHLPP2" OR ABSTRACT:"PHLPP2" OR TITLE:"PH domain and leucine rich repeat protein phosphatase 2" OR ABSTRACT:"PH domain and leucine rich repeat protein phosphatase 2" OR TITLE:"PHLPPL" OR ABSTRACT:"PHLPPL" OR TITLE:"PPM3B" OR ABSTRACT:"PPM3B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PHLPP2, not a curated reading list.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Colorectal cancer and the tag cansim-terms.
Shares mRNA to protein concordance, Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, PI3K / AKT / mTOR, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.