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DNAJC12 is a co-chaperone gene that is strongly expressed in oestrogen receptor-positive (luminal) breast cancers and is used as a luminal marker.
UniProt describes DNAJC12 as an Hsp40 co-chaperone that helps fold the aromatic amino acid hydroxylases. In breast cancer it is an oestrogen-responsive gene that separates luminal from basal-like tumours in expression data, and one of the genes whose protein closely follows its transcript.
In plain words · DNAJC12 is a co-chaperone gene that is strongly expressed in oestrogen receptor-positive (luminal) breast cancers and is used as a luminal marker.
DNAJC12 is a co-chaperone gene that is strongly expressed in oestrogen receptor-positive (luminal) breast cancers and is used as a luminal marker.
Probable co-chaperone for the folding of biopterin-dependent aromatic amino acid hydroxylases (PAH, TH, TPH1 and TPH2); expressed at high levels in brain, heart and testis (UniProt Q9UKB3).
No product in this corpus aims at DNAJC12 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Sources: HGNC HGNC:28908 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q9UKB3 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Probable co-chaperone for the folding of biopterin-dependent aromatic amino acid hydroxylases (PAH, TH, TPH1 and TPH2); expressed at high levels in brain, heart and testis (UniProt Q9UKB3).
Query for this target: (TITLE:"DNAJC12" OR ABSTRACT:"DNAJC12" OR TITLE:"DnaJ heat shock protein family Hsp40 member C12" OR ABSTRACT:"DnaJ heat shock protein family Hsp40 member C12" OR TITLE:"JDP1" OR ABSTRACT:"JDP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNAJC12, not a curated reading list.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.