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Endocrine therapy blocks the hormones that feed some breast and prostate cancers; endocrine resistance is when the cancer learns to grow without them.
Hormonal therapy in oncology manipulates the endocrine system with drugs that block hormone production or hormone receptors and is one of the main modalities of medical oncology alongside chemotherapy and targeted therapy (Wikipedia). In oestrogen receptor-positive breast cancer, resistance arises through ESR1 ligand-binding-domain mutations, loss of receptor expression and growth-factor pathway activation, which is why oral SERDs and CDK4/6 inhibitors are combined with or follow aromatase inhibitors.
In plain words · The hormone switch that drives most breast cancers. Blocking or destroying it is the oldest and most effective targeted therapy.
Showing the target this term concerns: Estrogen receptor (ERα).
Shares Hormone receptor status (ER / PR), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.