Loading
MIEN1 is a small HER2-amplicon gene whose protein promotes cell migration and is strongly raised in breast and prostate cancers.
17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt notes that MIEN1 is nearly absent from normal tissue outside the testis yet strongly up-regulated in breast cancer and in higher-grade prostate cancer, which makes it one of the more interesting passengers.
In plain words · MIEN1 is a small HER2-amplicon gene whose protein promotes cell migration and is strongly raised in breast and prostate cancers.
MIEN1 is a small HER2-amplicon gene whose protein promotes cell migration and is strongly raised in breast and prostate cancers.
Increases cell migration by inducing filopodia at the leading edge; regulates apoptosis, possibly through CASP3; among normal tissues present only in Leydig cells, strongly up-regulated in breast cancers and higher-grade prostate adenocarcinoma at the protein level (UniProt Q9BRT3).
No product in this corpus aims at MIEN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Sources: HGNC HGNC:28230 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q9BRT3 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Increases cell migration by inducing filopodia at the leading edge; regulates apoptosis, possibly through CASP3; among normal tissues present only in Leydig cells, strongly up-regulated in breast cancers and higher-grade prostate adenocarcinoma at the protein level (UniProt Q9BRT3).
Query for this target: (TITLE:"MIEN1" OR ABSTRACT:"MIEN1" OR TITLE:"migration and invasion enhancer 1" OR ABSTRACT:"migration and invasion enhancer 1" OR TITLE:"C17orf37" OR ABSTRACT:"C17orf37" OR TITLE:"C35" OR ABSTRACT:"C35") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MIEN1, not a curated reading list.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.