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STARD3 (MLN64) moves cholesterol between cell compartments and is co-amplified with HER2 in breast cancer.
17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes STARD3 as a sterol-binding protein that transports cholesterol from the endoplasmic reticulum to endosomes; it was first cloned as MLN64 from a breast cancer amplicon.
In plain words · STARD3 (MLN64) moves cholesterol between cell compartments and is co-amplified with HER2 in breast cancer.
STARD3 (MLN64) moves cholesterol between cell compartments and is co-amplified with HER2 in breast cancer.
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (UniProt Q14849).
No product in this corpus aims at STARD3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Sources: HGNC HGNC:17579 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q14849 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (UniProt Q14849).
Query for this target: (TITLE:"STARD3" OR ABSTRACT:"STARD3" OR TITLE:"StAR related lipid transfer domain containing 3" OR ABSTRACT:"StAR related lipid transfer domain containing 3" OR TITLE:"MLN64" OR ABSTRACT:"MLN64" OR TITLE:"es64" OR ABSTRACT:"es64") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STARD3, not a curated reading list.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.