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When a cancer copies the HER2 gene many times over, its neighbours on chromosome 17 are copied with it; those co-amplified genes are passengers, not the driver.
Gene amplification is any process that increases the number of copies of a gene without a proportional increase in other genes (Wikipedia). Amplification works on a stretch of chromosome, so the HER2 (ERBB2) amplicon at 17q12 in breast and gastric cancer usually carries GRB7, STARD3, PGAP3, MIEN1 and PNMT along with it. Their expression rises with ERBB2 and they turn up in expression signatures of HER2-enriched tumours, which a model can mistake for independent biology.
In plain words · A growth-signal receptor. Some cancers make far too much of it, and drugs that block it or use it as a docking site have transformed those cancers.
Showing the target this term concerns: HER2.
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Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.