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GRB7 is an adaptor protein gene that sits next to HER2 on chromosome 17 and is copied along with it in HER2-positive cancers.
17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes GRB7 as an adapter that interacts with numerous receptor kinases and promotes activation of STAT3, AKT and MAPK; it is one of the genes in the Oncotype DX HER2 group.
In plain words · GRB7 is an adaptor protein gene that sits next to HER2 on chromosome 17 and is copied along with it in HER2-positive cancers.
GRB7 is an adaptor protein gene that sits next to HER2 on chromosome 17 and is copied along with it in HER2-positive cancers.
Adapter protein that binds the cytoplasmic domain of receptor kinases and modulates downstream signalling, promoting activation of STAT3, AKT1 and MAPK1/3 and of HRAS (UniProt Q14451).
No product in this corpus aims at GRB7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Sources: HGNC HGNC:4567 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q14451 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Adapter protein that binds the cytoplasmic domain of receptor kinases and modulates downstream signalling, promoting activation of STAT3, AKT1 and MAPK1/3 and of HRAS (UniProt Q14451).
Query for this target: (TITLE:"GRB7" OR ABSTRACT:"GRB7" OR TITLE:"growth factor receptor bound protein 7" OR ABSTRACT:"growth factor receptor bound protein 7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GRB7, not a curated reading list.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), RAS / RAF / MEK / ERK (MAPK) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, PI3K / AKT / mTOR, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), RAS / RAF / MEK / ERK (MAPK) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.