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GRB7 is an adaptor protein gene that sits next to HER2 on chromosome 17 and is copied along with it in HER2-positive cancers. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Adapter protein that binds the cytoplasmic domain of receptor kinases and modulates downstream signalling, promoting activation of STAT3, AKT1 and MAPK1/3 and of HRAS (UniProt Q14451).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
The resistance atlas has no route that names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"GRB7" OR ABSTRACT:"GRB7" OR TITLE:"growth factor receptor bound protein 7" OR ABSTRACT:"growth factor receptor bound protein 7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GRB7, not a curated reading list.
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/grb7.json. Licence CC BY-NC 4.0.