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SPRY4 is a feedback brake on growth-factor signalling that the MAPK pathway switches on, so its expression is a read-out of how active that pathway is.
SPRY4, like SPRY2, is a Sprouty family feedback inhibitor: UniProt describes it as suppressing receptor-driven MAPK signalling upstream of Ras and RAF1. Because the pathway induces its own inhibitors, SPRY2, SPRY4 and the DUSP phosphatases are the transcriptional output genes used to infer MAPK activity from expression, and they fall when a MEK inhibitor works.
In plain words · SPRY4 is a feedback brake on growth-factor signalling that the MAPK pathway switches on, so its expression is a read-out of how active that pathway is.
SPRY4 is a feedback brake on growth-factor signalling that the MAPK pathway switches on, so its expression is a read-out of how active that pathway is.
Suppresses insulin receptor and EGFR-transduced MAPK signalling, probably by impairing GTP-Ras formation; inhibits Ras-independent activation of RAF1 (UniProt Q9C004).
No product in this corpus aims at SPRY4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Sources: HGNC HGNC:15533 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q9C004 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Suppresses insulin receptor and EGFR-transduced MAPK signalling, probably by impairing GTP-Ras formation; inhibits Ras-independent activation of RAF1 (UniProt Q9C004).
Query for this target: (TITLE:"SPRY4" OR ABSTRACT:"SPRY4" OR TITLE:"sprouty RTK signaling antagonist 4" OR ABSTRACT:"sprouty RTK signaling antagonist 4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SPRY4, not a curated reading list.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), RAS / RAF / MEK / ERK (MAPK) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), RAS / RAF / MEK / ERK (MAPK) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.