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Mass spectrometry weighs fragments of every protein in a sample to identify and quantify thousands of proteins and their phosphorylation sites, the closest measurement to what a cell is actually doing.
Mass spectrometry measures the mass-to-charge ratio of ions and is used to identify molecules (Wikipedia); in proteomics, peptides from digested proteins are quantified, often with isobaric tags across samples. CPTAC applied this genome-scale proteomics and phosphoproteomics to TCGA-linked tumours through several processing centres, giving paired RNA and protein for about a thousand tumours. It is the reference for mRNA-protein concordance and the only route to phosphosite-level pathway activity.
Showing the technology this term belongs to: Proteomics & phosphoproteomics.
Shares mRNA to protein concordance, Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.