Proteomics instruments and affinity platforms
Machines that measure thousands of proteins at once from tissue or blood, used to find drug targets and early-detection markers.
Mass spectrometry (Thermo Fisher Orbitrap Astral, Bruker timsTOF, SCIEX ZenoTOF) and affinity-based platforms (Olink/Thermo Fisher Explore, SomaLogic/Standard BioTools SomaScan, Alamar NULISA, Nautilus and Quantum-Si single-molecule approaches) deliver deep proteomes; UK Biobank's 50,000-participant Olink dataset and CPTAC's tumour proteogenomics illustrate the discovery value. Clinical proteomic tests remain few.
How it works
Peptide fragmentation and mass measurement (bottom-up MS) or barcoded antibody/aptamer pairs read by sequencing or PCR quantify proteins across large dynamic ranges.
- Direct measurement of drug targets and post-translational state
- Plasma proteomics at biobank scale
- Cost per sample
- Dynamic range and low-abundance proteins
- Standardisation across platforms
Latest papers
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