Loading
E2F7 is an unusual member of the E2F family that represses genes rather than activating them, helping cells pause after DNA damage.
UniProt describes E2F7 as an atypical E2F that mainly represses transcription, recognising the E2 site without a DP partner and participating in the DNA damage response. It is a cell-cycle gene whose transcript and protein can diverge, one of the examples of decoupled mRNA and protein in proteogenomic data.
In plain words · E2F7 is an unusual member of the E2F family that represses genes rather than activating them, helping cells pause after DNA damage.
E2F7 is an unusual member of the E2F family that represses genes rather than activating them, helping cells pause after DNA damage.
Atypical E2F transcription repressor that binds DNA independently of DP proteins and acts in angiogenesis, polyploidisation and the DNA damage response (UniProt Q96AV8).
No product in this corpus aims at E2F7 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Sources: HGNC HGNC:23820 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q96AV8 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Atypical E2F transcription repressor that binds DNA independently of DP proteins and acts in angiogenesis, polyploidisation and the DNA damage response (UniProt Q96AV8).
Query for this target: (TITLE:"E2F7" OR ABSTRACT:"E2F7" OR TITLE:"E2F transcription factor 7" OR ABSTRACT:"E2F transcription factor 7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about E2F7, not a curated reading list.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.