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DCLK1 is a kinase gene from neuronal development that also marks a rare stem-like cell population in the gut, studied as a colorectal and pancreatic cancer stem-cell marker.
UniProt describes DCLK1 as a probable kinase of neuronal migration expressed in the adult brain and, at lower levels, in the gut and other organs. In cancer research it is followed as a marker of tuft-like intestinal stem cells implicated in colorectal and pancreatic tumour initiation, and its transcript and protein levels track each other closely in proteogenomic data.
In plain words · DCLK1 is a kinase gene from neuronal development that also marks a rare stem-like cell population in the gut, studied as a colorectal and pancreatic cancer stem-cell marker.
DCLK1 is a kinase gene from neuronal development that also marks a rare stem-like cell population in the gut, studied as a colorectal and pancreatic cancer stem-cell marker.
Probable kinase in a calcium-signalling pathway controlling neuronal migration; in adults expressed in brain and detectable in heart, liver, spleen, prostate, ovary, small intestine and colon (UniProt O15075).
No product in this corpus aims at DCLK1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Sources: HGNC HGNC:2700 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt O15075 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Probable kinase in a calcium-signalling pathway controlling neuronal migration; in adults expressed in brain and detectable in heart, liver, spleen, prostate, ovary, small intestine and colon (UniProt O15075).
Query for this target: (TITLE:"DCLK1" OR ABSTRACT:"DCLK1" OR TITLE:"doublecortin like kinase 1" OR ABSTRACT:"doublecortin like kinase 1" OR TITLE:"DCAMKL1" OR ABSTRACT:"DCAMKL1" OR TITLE:"DCLK" OR ABSTRACT:"DCLK") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DCLK1, not a curated reading list.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Colorectal cancer and the tag cansim-terms.
Shares mRNA to protein concordance, Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.