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Cells control genes after the messenger RNA is made, by editing, transporting and degrading it and by modifying the finished protein, which is why RNA levels and protein activity can disagree.
Post-transcriptional regulation is control of gene expression at the RNA level, through capping, splicing, polyadenylation, localisation, stability and translation (Wikipedia). Post-translational modification then alters the protein itself by phosphorylation, ubiquitination, glycosylation and cleavage. Together they decouple protein abundance and activity from mRNA, the reason phosphoproteomics and reverse-phase protein arrays exist alongside RNA sequencing.
Shares mRNA to protein concordance, Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Pathway activation state (phosphosignalling), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares mRNA to protein concordance, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.