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PGAP3 is an enzyme gene in the HER2 amplicon that remodels the lipid anchors of cell-surface proteins.
17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes PGAP3 as acting in the fatty acid remodelling of GPI anchors, replacing an unsaturated acyl chain with a saturated one.
In plain words · PGAP3 is an enzyme gene in the HER2 amplicon that remodels the lipid anchors of cell-surface proteins.
PGAP3 is an enzyme gene in the HER2 amplicon that remodels the lipid anchors of cell-surface proteins.
Phospholipase involved in the fatty acid remodelling steps of GPI-anchor maturation; ubiquitously expressed, highest in thyroid and placenta (UniProt Q96FM1).
No product in this corpus aims at PGAP3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Sources: HGNC HGNC:23719 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt Q96FM1 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Phospholipase involved in the fatty acid remodelling steps of GPI-anchor maturation; ubiquitously expressed, highest in thyroid and placenta (UniProt Q96FM1).
Query for this target: (TITLE:"PGAP3" OR ABSTRACT:"PGAP3" OR TITLE:"post-GPI attachment to proteins phospholipase 3" OR ABSTRACT:"post-GPI attachment to proteins phospholipase 3" OR TITLE:"PERLD1" OR ABSTRACT:"PERLD1" OR TITLE:"CAB2" OR ABSTRACT:"CAB2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PGAP3, not a curated reading list.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.