Loading
PNMT makes adrenaline from noradrenaline in the adrenal gland; in breast cancer it matters only because it lies inside the HER2 amplicon.
17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt describes PNMT as the enzyme that converts noradrenaline to adrenaline; its expression in HER2-positive tumours reflects gene dosage, not adrenal biology.
In plain words · PNMT makes adrenaline from noradrenaline in the adrenal gland; in breast cancer it matters only because it lies inside the HER2 amplicon.
PNMT makes adrenaline from noradrenaline in the adrenal gland; in breast cancer it matters only because it lies inside the HER2 amplicon.
Catalyses the transmethylation of noradrenaline to adrenaline using S-adenosyl-L-methionine (UniProt P11086).
No product in this corpus aims at PNMT yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Sources: HGNC HGNC:9160 (approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)); UniProt P11086 (protein name, function and tissue specificity text (REST API, 2026-09-24))
Catalyses the transmethylation of noradrenaline to adrenaline using S-adenosyl-L-methionine (UniProt P11086).
Query for this target: (TITLE:"PNMT" OR ABSTRACT:"PNMT" OR TITLE:"phenylethanolamine N-methyltransferase" OR ABSTRACT:"phenylethanolamine N-methyltransferase" OR TITLE:"PENT" OR ABSTRACT:"PENT") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PNMT, not a curated reading list.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), HER2, Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map), Breast cancer (all types) and the tag cansim-terms.
Shares Co-amplification and the 17q12 HER2 amplicon, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.